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Compared to diet alone, in the group of 342 newly diagnosed overweight patients with T2DM treated with metformin, MI was reduced by 39%, coronary deaths by 50%, stroke by 41%, and all-cause mortality by 36% after a median 10.7 years (14)

Other highly selective RET inhibitors, such as TPX-0046 and BOS172738 are also being tested in clinical trials [38,39]

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I know you say that it should not affect the ability to get gene therapy in the future if you get the Pfiszer, Moderna, or Johnson and Johnson

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