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Our findings reveal that these prodrug molecules, featuring primary, secondary, and tertiary alcohols, as well as phenolic hydroxyls as leaving groups, are broadly susceptible to activation by a range of cellular reductants, including GSH and TrxR

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a , The ATP binding assay of PDK1 or PDK1 K163R mutant was detected by MANT-ATP (n = 3 technical repeats from one of three independent experiments)

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