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As a close structural relative of GHK-Cu (Gly-His-Lys), AHK-Cu shares the copper-chelating tripeptide architecture but exhibits a distinct biological activity profile studied particularly in the contexts of hair follicle biology, angiogenesis, and skin extracellular matrix research

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The mechanism involves suppression of reactive oxygen species (ROS) that the enteric nervous system uses to trigger peristaltic contractions, combined with microbiome shifts away from butyrate-producing bacteria

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