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Although SFN shows various properties, the most important property is its potential against cancer

In this review, aging refers to the biological aging process, healthy aging denotes the preservation of functional and circadian integrity, and circadian disruption describes pathological alterations or misalignment of circadian rhythms

As mentioned earlier, sperm membranes are rich in PUFAs, which are particularly prone to oxidation by ROS

This suggests that their enrichment may reflect shared mitochondrial gene activation rather than distinct disease-specific processes

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Hence, the facilitation of glutaminolysis leads to the accumulation of excess ammonia within cells, and a high concentration of ammonia is a potent inducer of autophagy 167 (Fig