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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

The cardioprotective effects operate through the CD36 receptor, which is broadly expressed throughout the cardiovascular system

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The 250mg Setria dose provides the antioxidant foundation that protects kidney cells from oxidative damage while supporting the organ's crucial detoxification functions

OMP, outer membrane protein

12: Jenner P, Olanow CW (1998)