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Concentration-Efficacy Relationships The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with opioid agonists

DOI:10.1002/ptr.6409 71

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GLP-1 medications are considered safe for most patients with Hashimotos or hypothyroidism, as long as there is no history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, which are contraindications due to a potential cancer risk observed in animal studies