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No regulatory authority Health Canada, the FDA, the EMA, the TGA, or any equivalent has cleared 5-Amino-1MQ for therapeutic use in humans or animals

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Total GSH, GSSG, and GSH was quantified from plasma protein-bound glutathione, erythrocyte lysate, and free plasma

Acknowledgements We would like to thank the Kyoto Integrated Science & Technology Bio-Analysis Center for allowing us to use their LC-MS/MS (3200 QTRAP) and Editage (www.editage.jp) for English language editing

doi: 10.1002/hep.28574 90 JedlitschkyGBurchellBKepplerD

In experiments involving a mouse model of skin aging induced by D-galactose, treatment with higher concentrations of sea buckthorn PCs (50 and 100 mg/kg) led to an increase in TGF-1 levels within the skin tissue and the upregulation of Smad3 expression