Be aware that NICE guidance (TA875) specifies that Wegovy should be prescribed through specialist weight management services and treatment is limited to a maximum of 2 years
The same protein-first, scheduled-eating strategy that applies to GLP-1 alone applies to the combination, but with extra attention to caloric floor (1200-1400 for women, 1500-1800 for men) and protein intake (1.2-1.6 g per kg body weight daily)
can persist longer than other gastrointestinal effects Abdominal pain - common Eating smaller meals, avoiding fatty or spicy foods, and not lying down immediately after eating can help manage gastrointestinal side effects
For me, understanding this mechanism helped me feel more confident that I wasn't just taking a placebo
In other words, it it increases, but by less and less as you go
Additionally, an indirect comparison between the free up-titration approach of basal insulin and GLP-1RA and switching to FRC was conducted for glycemic efficacy and safety