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75 , e13988 (2021)

Excess inflammation is a well-known contributor to aging, as it can damage tissues and organs over time

However, the identification of ferroptosis in 2012 [7] marked a paradigm shift in our understanding of cardiovascular pathology

Clinical data shows that some GLP-1 agonists may actually provide modest cardiovascular benefits, though blood pressure monitoring remains essential during treatment initiation and adjustment

Going forward, there are new research opportunities to incorporate blood-based biomarkers into studies investigating population-level interventions

Additionally, evidence supporting lactylation-dependent mechanisms has been compiled