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Proactive management with hydration, fiber, and magnesium can significantly shorten and reduce the severity of this period

In the obesity trials, participants on the 12 mg dose reached up to roughly 2829% mean body-weight reduction at 68 to 80 weeks, with a large share crossing the 25% and 30% thresholds, the strongest weight result reported for a GLP-1-class compound in a phase 3 trial [5]

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It is important to emphasise that, as an unlicensed investigational medicine in the UK, any adjustments to dose timing or frequency must follow the clinical trial protocol and be directed by your prescribing clinician or trial team

Each subsequent dose tends to produce milder side effects as the body adapts

Insert the needle smoothly in one motion