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The whole injection sites of limb or injections sites below no pain part have been chosen to block that pain

For any licensed injectable medicine, storage conditions and shelf life after reconstitution are defined in the product's SmPC

It is a requirement backed by clinical trial data showing that slower titration reduces gastrointestinal side effects by 40 to 60% compared to starting at full dose

35 VergunstCEGerlagDMLopatinskayaLKlareskogLSmithMDvan den BoschFet al

Langa KM, Larson EB, Crimmins EM, et al

Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor