Moreover, GLPs exert hepatoprotective effects via the gutliver axis by modulating dysbiotic gut microbiota composition, reinforcing intestinal epithelial integrityincluding tight junction protein expression, and reducing bacterial translocation and endotoxin leakagethereby attenuating hepatic inflammation and injury (Zhang N
Gut-associated immune system activation The gut, being the largest immunological organ, plays an important role both in digestion and nutrient absorption (94)
The CDC estimates that 190 Americans died per day in 2021 from TBI-related injury and there were more than 214,000 hospitalizations related to TBI in 2020.1 Brain injury can be temporary or may result in severe and permanent disability or death and is typically classified as primary or secondary brain injury
Lifestyle interventions that reshape ROS tone (mechanism-anchored) Lifestyle levers can reset ROS tone in ways drugs often cant: exercise training induces mitochondrial biogenesis and mitophagy, improves endothelial NO bioavailability and upregulates endogenous antioxidant systems so that the pulsatile ROS generated during bouts acts as a mitohormetic signal rather than a damaging load (Guan et al
Griffiths, K
Collectively, these studies indicate that comprehensive TCM-based approaches, particularly when integrating herbal medicine, acupuncture, and adjunctive modalities, can address both subjective symptoms and measurable physiological parameters of tinnitus
