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To those who are still bleating that we should keep trying diet and exercise before resorting to use of anti obesity medications or that we can maintain long term weight loss effected by use of medication by ceasing medication and relying on diet and exercise alone- please look up all the research which shows that lifestyle intervention alone can only effect 5-7% weight loss and this weight will also be regained in the next year or two

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Thumbnail: Gary Brecka by Gage Skidmore (CC BY-SA 2.0) References 1The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation | Poljak et al

This development led to a surge of interest, research, and funding for drugs that could treat these metabolic diseases through different biological pathways

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

Although the shortages ended in 2025, many compounders continue marketing the unauthorized knockoffs