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The polyethylene glycolylated mouse leptin antagonist (PEG-MLA)-treated mice exhibit increased fasting and glucose stimulated plasma insulin levels, decreased whole-body insulin sensitivity, elevated hepatic glucose production, and impaired insulin-mediated suppression of hepatic glucose production (Levi et al., 2011)

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For adults, typical doses range from 2.5 mg to 10 mg, which may be repeated if necessary

In contrast, compounded medications are not FDA-approved