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Trials were included if they measured body weight, waist size, fat mass, or other indicators of body composition, and compared outcomes against a placebo

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Compared to the control AB(WT) fish, the LMNA (WT) and the LMNA mutant transgenic fish (except LMNA (W520G) because no fish survived after F0) showed significantly higher levels of LMNA mRNA expression (Fig