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Consistency in skincare and patience are important during this phase
Many commercial formulations are stable at room temperature
The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse
The B12 component may help if low B12 is contributing, though much of this early tiredness comes from the calorie drop itself and tends to ease as your body adjusts
Weeks 1-4: tirzepatide only phase During the tirzepatide-only phase, the primary change is appetite reduction
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