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These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium

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These effects were substantial and help elucidate the remarkable glucose homeostasis abilities of tirzepatide observed in SURPASS-2 trial when compared with semaglutide (112)

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