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NCE-1 date: NCE-1 date also known as the four year date occurs four years after the original drug approval and marks the first opportunity for a generic manufacturer to file an ANDA with a Paragraph IV certification

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Discontinuation, however, may result in a gradual return to the natural skin tone

Although there was not a statistically significant difference, there were more patients who had BCAA supplementation in the l-carnitine group (50%) compared to the control group (28%)

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