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This is thought to be a defense response to increase levels of cellular oxidation and to minimize oxidative damage during pathogenesis of disease

Insulin-like Growth Factor-1 (IGF-1) is a hormone produced primarily in the liver in response to growth hormone (GH) stimulation

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vii) no serious concomitant medical conditions mimicking AAV such as malignancies, severe infectious diseases requiring hospitalization, and autoantibody-medicated autoimmune diseases, or inducing ANCA false positive at diagnosis