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They observed that COMBI therapy was superior to LIRA and MET monotherapy in reducing weight, BMI, and WC in women with PCOS previously poor responders to weight loss on metformin monotherapy

Because it engages an additional glucagon pathway beyond dual-agonist compounds, retatrutide is frequently studied alongside Semaglutide (a mono-agonist) and Tirzepatide (a dual-agonist) to compare multi-receptor pharmacology

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Note: There are no approved or commercially available patches that contain semaglutide