Evidence-based ways to ease it, and when to call your care team
These intake suppressive effects are not macronutrient specific since the intake of both palatable (high-fat or high-sugar) food and normal chow (Alhadeff et al., 2010
It also emphasizes nutrient adequacy, management of gastrointestinal effects, appropriate diet, and resistance training during treatment
Notably, tirzepatide observably increased the abundance of beneficial genera such as Akkermansia, elevated the ratio of farnesoid X receptor (FXR) antagonists (glycoursodeoxycholic acid: GUDCA, -muricholic acid: -MCA, hyodeoxycholic acid: HDCA, ursodeoxycholic acid: UDCA) to natural agonists (cholic acid: CA, lithocholic acid: LCA, chenodeoxycholic acid: CDCA, glycocholic acid: GCA, taurodeoxycholic acid: TDCA), and reduced FXR expression in intestinal tissues
The mechanism is plausible
Effects of DPP-4 inhibition on cardiac metabolism and function in mice