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Animal-lifespan findings vary by strain and outcome

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The documented doses, such as 0.01 to 1 mg/kg intravenously in animal models or 0.03 mg/kg intravenously in the clinical ileus study, are pure study parameters and serve to describe the state of research

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too much self-renewal would result in germline tumors of proliferating cells and a reduction or elimination of differentiated gametes that are formed, while too much differentiation would result in the GSC population being depleted and a lack of sustained gamete formation