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Common types of MC4R dysfunction Many variants (e.g., Ser127Leu) exhibit multiple concurrent functional defects, and the majority follow a dominant inheritance pattern consistent with haploinsufficiency [29]

Oral bioavailability of peptides is generally very low because gastric proteases cleave amide bonds rapidly

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Some people are born with variants in antioxidant genes that change how efficiently their bodies neutralize oxidative stress

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