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More rigorous, standardized, and long-term studies are needed to optimize these interventions

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They are not recommended if you have a personal or family history of thyroid cancer or a thyroid condition called medullary thyroid carcinoma

A 2025 meta-analysis published in Frontiers in Pharmacology confirmed this hierarchy, ranking tirzepatide as producing the most significant weight reduction among all available incretin-based therapies, followed by semaglutide, then liraglutide

Nanda, S., Chadha, N., Sen, J

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