requires monitoring in patients with cardiovascular conditions The glucagon receptor component of retatrutide raises particular considerations
doi: 10.1056/NEJMoa1612917 19 LeiterLACarrMCStewartMJones-LeoneAScottRYangFet al
For some, the skin may appear thinner or less elastic, which is a natural response to reduced fat beneath the surface
In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
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Small-Molecule GLP-1 Drugs Target the Brains Emotion and Reward Centers Peptide GLP-1 agonists are difficult to manufacture, store, and administerthey must be injected