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Since baseline collagen production is known to decline roughly 1% per year starting in the mid-20s, a compound that reactivates a suppressed signaling pathway rather than simply adding raw material is mechanistically interesting in a way that most topical actives aren't

Its even more vital for pregnant or lactating women who are vegetarian/vegan to consume enough B12, as infants are at higher risk for B12 deficiency (7)

The important distinctions are labeled dosing versus compounded-unit math, escalation and missed-dose rules, measurement errors, tolerability, and the symptoms that should trigger a call to a licensed prescriber

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Very few think critically about magnesium, and the ones who do are often taking a form that barely makes it past their gut