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Gclm KO mice are viable 17,18 , having 1540% of normal tissue GSH levels due to GCLC expression

Gabay, Genve (Rhumatologie)

One of the earliest biochemical changes seen in PD is a decrease in the levels of total GSH which occurs even before a reduction in mitochondrial complex 1 activity, dopamine levels, or the neurodegeneration that are all associated with the disease (Chinta et al., 2007)