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Operation Supplement Safety (OPSS)

[13] Clinical trials [edit] Phase IIB trial (TIPO-1) results reported in The Lancet [19] showed levels of weight loss over a 6-month period that were significantly greater than those achieved with any other drugs available at the time

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Revised: 4/2026 Full Prescribing Information WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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