GLP-1R can also signal through G q , which may enable this receptor to function under conditions of hyperglycemia (Oduori et al., 2020), a hypothesis challenged by the observation that GIPR has also been shown to signal through G q (Shaaban et al., 2016
doi: 10.1111/j.1463-1326.2009.01132.x
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Rodriguez-Iturbe B, Vaziri ND, Herrera-Acosta J, Johnson RJ