2018;142(2):665-668.e8
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*Correspondence: Zhenwei Mao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
17 Alternatively, surgery to remove the prolactin-secreting tumor (a non-cancerous tumor in the pituitary gland) has also been shown to successfully lead to remission
This immune privilege is characterized by several key immunoregulatory features, including downregulation of major histocompatibility complex (MHC) class I and II molecules in the proximal follicular epithelium, absence of ligands that would activate cytotoxic immune responses (such as MICA and ULBP), low expression of adhesion molecules that facilitate immune cell infiltration, and the local production of immunosuppressive cytokines (e.g., TGF- and -MSH)