Growing evidence from observational studies indicates that treatment of obesity with bariatric surgery improves cardiovascular outcomes, but these findings have not been confirmed in randomized trials, largely because of randomization challenges with bariatric surgery
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Beyond glycemic control, activating GLP-1R exerts anti-inflammatory and antifibrotic effects on diverse fibrotic diseases, such as renal fibrosis, cardiac fibrosis, liver fibrosis and BLM-induced pulmonary fibrosis [25, 26]
The disease is marked by the onset of excessive inflammation followed by collagen deposition and ultimately causing fibrosis in the lung at about 3 to 6 months post radiotherapy [61, 62]
Methods Animal experiment Male SHR and WKY rats, aged 2, 3, 4, 6, 8, 10, 12 and 16 weeks, were obtained from the Laboratory Animals Research Unit of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia and housed at room temperature with a 1212 h lightdark cycle (06001800 hours), and with access ad libitum to food and water throughout the experimental period
doi: 10.1097/00000478-199003000-00002 10 Aidan CarneyJGordonHCarpenterPCVittal ShenoyBGoVLW
