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Systematic review of 4 studies (3 RCTs + 1 single-arm trial)

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therefore, in comments following publication of the study, there was a suggestion that these adverse reactions could be largely due to the use of laropiprant [8, 9]

Was the concentration calculated correctly

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Nonetheless, these clinical trials were underpowered to detect rare events such as suicidal ideation and self-injurious behavior, and they systematically excluded patients with psychiatric comorbidities commonly seen in clinical settings