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The organization also warns that since its not approved for human clinical use by any global regulatory authority, it may lead to negative health effects including immunogenic reactions (antibodies), peptide impurities, and limited safety data for proposed routes of use

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346,347,348 The first is the exogenous route, in which the NADs are directly introduced into the obtained exosomes via electroporation, co-incubation, sonication, extrusion, and freeze-thaw cycling

Improved circulation enhances nutrient delivery to ocular tissues and may support optic nerve health