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ABILIFY MAINTENA was associated with mean increase from baseline in weight of 1.0 kg at week 52

FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation

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