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Research has suggested that DSIP may interact with sleep-wake cycles and circadian rhythms, making it a unique tool for laboratory studies focused on sleep biology

org/10.1186/s13643-023-02238-w Oh, H., Park, C

[Google Scholar] 50.Jankyova, S

Table 3 sEVs derived from different types of origins served as drug delivery system

221 This is the case of MKN28 cancer cell line, where no mRNA nor protein expression was found due to high methylation of NAPRT promoter region

Most studies involving IGF-1 LR3 have focused on its effects in peripheral tissues rather than its direct actions within the central nervous system, so more research is needed to determine its distribution in the brain