Inhibitors of NAD+ biosynthesis, particularly those targeting nicotinamide phosphoribosyltransferase (NAMPT), have shown potential in preclinical models, although resistance mechanisms such as alternative NAD+ biosynthetic pathways can limit their effectiveness
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PMID 10047539
Importantly, folic acid should not be given alone before B12 deficiency is excluded or treated, as this can mask anaemia while allowing neurological damage to progress
The data showed adverse event rates of "well under 0.1%," he added