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AICAR and metformin were from Cayman Chemical (Ann Arbor, MI)

Ozempic, in particular, carries a boxed warning (also called a black box warning) for an increased risk of thyroid cancer

Flavonoids, such as quercetin, catechins, and anthocyanins, are among the most studied phenolic compounds [195]

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Bone defect models are commonly used in such studies

Reported cases have occurred primarily in diabetic patients with significant renal insufficiency, including both intrinsic renal disease and renal hypoperfusion, often in the setting of multiple concomitant medical/surgical problems and multiple concomitant medications