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Skov J, Persson F, Frkir J, Christiansen JS

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BTD encodes biotinidase, the enzyme that frees biotin from dietary proteins and reclaims it from the body's own proteins

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MIN6 cells were stimulated with 10 nM GLP-1 or GIP in HBSS after 2 h-pretreatments with 0 M (circle), 10 M (triangle), 100 M (rhombus), or 1 mM metformin (square), and luminescence was measured for 40 min

Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states