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Proteins tend to fold into complex three-dimensional shapes and bear multiple functions, while peptides are plain and usually operate via specific interactions

The FINEARTS-HF trial highlighted that although finerenone did not significantly affect definitive kidney outcomes in patients with HFmrEF or HFpEF, it led to meaningful reductions in albuminuria

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Notably, the treatment preferentially preserved the inner tibial cartilage zone and was associated with a trend toward reduced osteophyte formation [139]

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