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MT COMPETING INTERESTS: Associate Professor Markovic is an investigator on pharmaceutical trials of semaglutide and CagriSema (NovoNordisk), tirzepatide and retatrutide (Lilly), BI 456906 (Boehringer Ingelheim) and maridebart/cafraglutide (Amgen)

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It was originally found as an impurity in preparations of insulin from chicken pancreas

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The mechanism involves enhanced fatty acid oxidation, improved insulin sensitivity in skeletal muscle, and, perhaps most impressively, the browning of white adipose tissue through the ERK signaling pathway