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Supplementing with vitamin C has not been found to be toxic, but taking more than 2,000 mg per day may cause abdominal cramps, diarrhea and nausea, as well as increase the risk of developing oxalate kidney stones in men ( Additionally, doses over 250 mg per day may interfere with tests designed to detect blood in the stool or stomach and should be discontinued two weeks before testing ( Summary Fresh fruits and vegetables are excellent sources of vitamin C and should prevent deficiency when consumed on a daily basis

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Sourris KC, Ding Y, Maxwell SS et al (2024) Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation

Every ongoing trial approved under the old Directive had to transition to CTIS by January 31, 2025

The Journal of clinical investigation , 132 (19), e152341.