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Retatrutide markedly suppressed the expression of pro-inflammatory cytokines (TNF- , caspase-1, and NLRP3) and pro-fibrotic factors (fibronectin, -SMA, and collagen I) in treating diabetic kidney disease (DKD) in db/db mice (54)

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This prevents bacterial growth but does not stop chemical degradation of the peptide

The prespecified selection criteria included: (1) RCTs reporting desired cardiovascular or renal outcomes

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