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Retatrutide vs Tirzepatide (Mounjaro and Zepbound) Tirzepatide was the first dual agonist to hit the market, combining GLP-1 and GIP

The STEP 8 study showed that in addition to being superior to placebo, SMG was also superior to daily administration of liraglutide for weight loss [94]

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[] This categorisation has been supported by findings from various clinical studies that reveal no detrimental effects, even among the elderly, when consuming roughly 50400 mg/day, which is equivalent to 6.7 mg/kg TRF for a 60 kg adult over durations ranging from 2 weeks to 18 months

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