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In clinical trials, however, preclinical cardiovascular benefits were not sustained, and increased hospitalizations for HF and fractures were observed

(2004) 286:E6215

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doi: 10.1074/jbc.M116.730564 74 YinW.XuS.WangZ.LiuH.PengL.FangQ.et al

to estimate insulin sensitivity in patients treated with placebo, TZP or semaglutide after 28 weeks of treatment, achieving a hyperinsulinemic, euglycemic clamp experiment, followed by a hyperglycemic clamp (216 mg/dL) to estimate insulin secretory responses