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The combination is particularly relevant for skin wounds that are slow-healing, extensive, or post-surgical, where natural repair capacity is insufficient and multiple phases of the healing cascade need simultaneous support

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However, evidence demonstrates how viral-induced inflammation can incite chronodisruption to inhibit melatonin and induce oxidative stress and inflammation in the placenta (51, 71, 113, 115, 128, 136138)

For researchers, choosing between the two depends entirely on the specific pathways and outcomes being investigated