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Discussion We report a randomised crossover trial evaluating a commercially available AID system in individuals with advanced CKD and either type 1 or type 2 diabetes in a free-living environment

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Specifically, we dissect how baseline microbial signatures correlate with differential efficacy, while critically assessing clinical confounding factors, such as metformin co-treatment and dietary shifts, and the methodological limitations that currently hinder the translation of microbiome profiling into precision endocrinology

This is especially useful for compounds such as siRNA, miRNA and chemotherapeutic agents that need to act on the target at a site in order to reduce off-target effects