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Chemical interactions involving OH-groups include etherification, esterification, cross-linkages, graft co-polymerization, complexation with poly-anions, and O-acetylation
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Due to the orthophosphoric groups, these agents can dissociate to form anions with charges of -1, -2, or -3
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In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]