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Both human and animal studies reported inconsistent BP response to acute administration but showed hypotensive effect of chronic administration of GLP-1/ GLP-1 RAs

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Symptoms include: Aching, throbbing, or burning Cramping (especially in calves) Jerking Buzzing or vibrating Itchy Pins and needles Creepy crawly Irresistible urge to move your leg to relieve the discomfort While mild symptoms can be more challenging to identify, moderate to severe symptoms are very noticeable, and therefore, are more readily identifiable and able to be diagnosed