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The Phase 3 TRIUMPH-4 trial pushed these numbers even further: participants on retatrutide 12mg lost an average of 28.7% of their body weight at 68 weeks

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If you plan to resume, restart at the full dose rather than titrating back up, since the break period allows receptor resensitization

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This differential efficacy reinforces the conclusion that the mitochondrial ROScytochrome c caspase signaling axis constitutes the specific pathway downstream of SLC25A39 loss