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Milk thistle (Silybum marianum)

Mood and Cognitive Function : They positively affect mood and cognitive function due to their influence on growth hormone levels and neuroprotection

Loss or a single nucleotide polymorphism on the SLC25A48 gene inhibits mitochondrial choline import, increases reactive oxygen species, disrupts lipid balance, and impairs cell proliferation (1820)

The slightly longer timeline to reach maintenance dose is a worthwhile trade for better tolerability

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Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: A preliminary report